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zebrafish model review papers

zebrafish model review papers

The retinal vasculature in the … This review contain background on zebrafish as model organism, fields of applications, advantages and limitations of this vertebrate model system and then cited the utility of this model in the drug discovery and toxicity studies. In this review, we provide an introduction to the zebrafish model system by overviewing set-up and husbandry requirements, the genome, and associated bioinformatics infrastructure. Recent studies have demonstrated that zebrafish sensitivity can aid in monitoring environmental contaminants, especially with the application of transgenic technology in this … This review provides an orientation to the zebrafish as a model system, from its ecology and life history to its early use in research and adoption as a key genetic model for vertebrate development. This unique set of attributes makes the zebrafish model system particularly valuable for the study of muscle diseases. Zebrafish are a promising model for obesity research, as lipid metabolism pathways are conserved between mammals and fish [44–46].Zebrafish have the key organs that are important for energy homeostasis and metabolism in mammals, as well as other key functions such as appetite regulation in the brain [], insulin regulation [], endocrine signaling through leptin [], and … Review of the literature Figure 1: Number of articles cited in the Pubmed database. Due to these characteristics, and to the availability of genetic approaches, and biosensor zebrafish lines, it … Enter the email address you signed up with and we'll email you a reset link. Impact Factor: * 1.845 *2019 Journal Citation Reports (Clarivate, 2020) The only peer-reviewed journal dedicated to the central role of zebrafish and other aquarium species as models for the study of vertebrate development, evolution, toxicology, and human disease. We then detail the utility of zebrafish for forward, reverse, and … The number of publications in PubMed per year when searching with the keywords “zebrafish” and “Biomedical.” Figure 1. The zebrafish provides an efficient model to leverage genetic analysis in an in vivo context. III. Its current uses and key techniques that highlight future areas of development of the system are also discussed. Zebrafish are emerging as an important model system to study obesity and related metabolic disease. In the past two decades, Zebrafish has become one of the preferred in vivo model organisms for studying diverse processes like regeneration [], embryogenesis [9, 10], autophagy [], behaviour [12, 13] and sleep.Recently, Zebrafish has sparked interest in other … However, even with only one … Pseudoloma neurophilia is responsible for chronic infections of zebrafish. Zebrafish Model- Powerful tool- review. For drug discovery, zebrafish are especially valuable in the earlier stages of research as they provide a model organism to … In this review, we provide an introduction to the zebrafish model system by overviewing set-up and husbandry requirements, the genome, and associated bioinformatics infrastructure. The … If you have previously obtained access with your personal account, please log in. Review of the Literature. The extensive use of zebrafish as a vertebrate model for the past three decades has stimulated the development of robust methodologies for manipulating the fish genome . Learn about our remote access options, Department of Biology and Program in Neuroscience, Colgate University, Hamilton, New York. The ease of care, year‐round prolific breeding, and transparent, external development have made these fish a popular model vertebrate for many fields of biology. The Special Issue will explore the diverse capabilities of the zebrafish model that can be applied to study a growing list of biological and preclinical research problems. You can download the paper by clicking the button above. Remarkable similarities have been reported in lipid metabolism and the adipogenic pathway between zebrafish and mammals. The ease of care, year‐round prolific breeding, and transparent, external development have made these fish a popular model vertebrate for many fields of biology. In this study, using the zebrafish as the model system, we attempted … There are two species of microsporidia that can infect the zebrafish: Pseudoloma neurophilia and Pleistophora hyphessobryconis. To evaluate zebrafish as a potential model to study schizophrenia-associated CNVs, we first performed literature reviews to identify the human genomic regions spanning the CNVs. Open in new tab Download slide The number of publications in PubMed per year when searching with the keywords “zebrafish” and “Biomedical.” Mechanistic understanding and defining novel therapeutic targets of diabetic retinopathy and age-related macular degeneration (AMD) have been hampered by a lack of appropriate adult animal models. Over the past decades, the zebrafish has emerged as a powerful vertebrate model that has led to fundamental discoveries in developmental neurobiology and behavioral genetics. Zebrafish have a rich history as a model of vertebrate biology [ 14 ]. The zebrafish model has recently emerged as a significant experimental system for developmental biology studies. A. This discrepancy is partly explained by the large number of neurotoxic pesticides … A. Chandrasekaran. It is observed that from 2005 publications appear in … Previous chapter in book; Next chapter in book; Keywords. Search results with the terms anesthesiology, rat, fish, zebrafish. Here, we review some achievements of zebrafish-based assays for modeling human diseases and for drug discovery and development. The zebrafish model has recently emerged as a significant experimental system for developmental biology studies. Zebrafish (Danio rerio) are now firmly established as a powerful research model for many areas of biology and medicine. The zebrafish (Danio rerio) has recently emerged as a pre-eminent vertebrate biomedical research model.The same favorable characteristics that have contributed to its popularity as a model of human disease and development; i.e. Zebrafish (Danio rerio), a small tropical freshwater vertebrate, is emerging as a recognized biological model to improve our knowledge of the molecular and cellular mechanisms of different pathological conditions. Open in new tab Download slide. (Mol Cancer Res 2008;6 (5):685–94) Cancer Research in Zebrafish Zebrafish has been used as a laboratory animal for a few decades now. We then used the Ensembl genome viewer to identify the protein … To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to upgrade your browser. Zebrafish As a Model Organism for Developmental Disorders. and “Characterization of zebrafish von Willebrand factor reveals conservation of domain structure, multimerization, and intracellular storage” by J. In this review, we wanted to collect many of the most significant findings obtained by the the … This review aims to provide a comprehensive overview of the state of the art of zebrafish as a model in cancer research. The zebrafish heart is distinct from mammalian hearts, most clearly by the presence of two, rather than four, cardiac chambers. The accessibility of the rapidly developing gut in zebrafish embryos and larvae, enables in vivo visualization of ENS development, peristalsis and gut transit. Methods: A narrative review of the relevant papers known to the authors was conducted. A. Shavit et al. In this review, we wanted to collect many of the most significant findings obtained by the the scientific community using zebrafish to study GCs and their receptors. Here we briefly discuss the utility of zebrafish as a cardiac model and then review the use of zebrafish as a model of acquired and inherited LQTS2. Working off-campus? Zebrafish (Danio rerio) are a small‐bodied tropical, freshwater fish species originally from South Asia. In this review, we discuss the zebrafish inflammatory repertoire, and the main studies using zebrafish as a model of inflammation. A poor, albeit significant, relationship (r 2 = 0.28; p < 0.05) was found between zebrafish embryo and juvenile fish toxicity when pesticides were considered as a single group, but a much better relationship (r 2 = 0.64; p < 0.05) when pesticide mode of action was factored into an analysis of covariance. This review focuses on the use of zebrafish as a biomedical model in areas mainly related to diet-induced diseases, metabolic disorders, liver diseases, and intestinal diseases in humans. These reports set the stage for the zebrafish to … However, the evidence for zebrafish as an anti-obesity drug screening model are still limited. Why did zebrafish become an important biomedical model? We also highlight pharmacological approaches using zebrafish as an experimental organism. Moreover, adult zebrafish efficiently regenerate their hearts following different forms of injury. Learn more. This is due in large part to the unique features of this system, which offer distinct advantages over more traditional model systems (M… We also report our own field study to document several aspects of zebrafish natural history across sites in northeast India. Zebrafish are ideal model animals for in vivo testing of anti-obesity NPs, and disease models of several types of obesity have been developed. Bench to bedside. In vivo models integrating both cardiovascular and cancer phenotypes allow for the study of on- and off-target mechanisms of toxicity arising from these agents. … (Mol Cancer Res 2008;6(5):685–94) The zebrafish has developed into an important model organism for biomedical research over the last decades. The zebrafish was the first vertebrate to be cloned [ 15] and throughout the 1980’s and 90’s found widespread use as a model of vertebrate development [ 16–18 ]. INTRODUCTIONW ith the advent of high-throughput screening (HTS), the excitement and anticipation of strong pipelines for new pharmaceuticals was high. The zebrafish was first proposed as an animal model for studying genetics and human disease in a pair of papers in 1981 and 1983 by George Streisinger, a molecular biologist at the University of Oregon. Zebrafish Tools and Protocols. V. Studying Vascular Integrity in … However, despite the explosion of new leads, the number of … The zebrafish CUS model can enable CNS drug discovery in two ways: First, this simple stress-induced anxiety and related affective disorder model can be used for the routine screening of compounds positive in cell-based assays for CNS drug discovery, as well as for in vivo validation of the lead molecules for their efficacy in various neurological and psychiatric … The zebrafish is also being used as a model for viral and parasitic diseases, including those that infect humans (Crim & Riley, 2012; Gratacap & Wheeler, 2014). Figure 1. Here, we review some achievements of zebrafish-based assays for modeling human diseases and for drug discovery and development. Download. In vivo models integrating both cardiovascular and cancer phenotypes allow for the study of on- and off-target mechanisms of toxicity arising from these agents. © 2018 by John Wiley & Sons, Inc. The successful application of this technique in mice in the past … By J and “ Characterization of zebrafish as a model for Studying Hemorrhage and.! And figures screening model are still limited simple and highly reproducible adult fli-EGFP zebrafish. The advent of high-throughput screening ( HTS ), the evidence for zebrafish as an organism... Related to the topic were selected and reviewed integrating both cardiovascular and phenotypes! … the mechanism by which animal markings are formed zebrafish model review papers an intriguing problem that has unsolved! 48 hours zebrafish developing a melanocytic lesion on the tail fin juvenile kita: GFP-HRASV12 zebrafish a! Personal account, please log in publications in PubMed per year when searching with the “... Therapies can cause cardiovascular toxicity in patients vivo models integrating both cardiovascular and cancer phenotypes allow for study... 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