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md anderson structural biology

md anderson structural biology

Post-doctoral Fellow in Structural Biology. The University of Texas MD Anderson Cancer Center (Houston, TX) Posted: December 11, 2020. Here, we review the reasons this discovery has been underappreciated, as well as discuss the robust results supporting its premier biological importance and utility for current research. These structural features create remarkable enzymes that promote catalysis at faster than diffusion-limited rates by using electrostatic guidance. hliang1@mdanderson.org. As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test new treatments for both common and rare cancers. We highlight our understanding of SOD function gained through structural biology analyses, which reveal important hydrogen-bonding schemes and metal-binding motifs. PMID: 28104618. in biochemistry from the University of Notre Dame and earned his Ph.D. in molecular and cellular biology from Tulane University. HySA: A Hybrid Structural variant Assembly approach using next generation and single-molecule sequencing technologies. In addition to the interdisciplinary and multidisciplinary training approaches taught through formal courses,  laboratory research experience and exposure to clinical  problems, the CBP offers diverse  educational  activities and services to students, which include an annual scientific retreat, student seminar series, barbecue cookouts, new student orientation/welcome party, and opportunities to attend scientific conferences both nationally and locally. Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas. SOD structures may also control their enzymatic activity through product inhibition; manipulation of these product inhibition levels has the potential to generate therapeutic forms of SOD. ggomez@cnio.es. Department of Anatomy and Structural Biology and Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, Bronx, NY. 11 Program in Cancer Biology, Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. The University of Texas MD Anderson Cancer Center Employer: The University of Texas MD Anderson Cancer Center. Importantly, MCO’s research has led to several ongoing Application Deadline: Open Until Filled. A.}". The department emphasizes the training of students, postdoctoral fellows and clinical fellows in the fundamentals of tumor biology to improve the outcomes of patients with malignancies. Request an Appointment. The program provides training in all aspects of cancer biology, including tumor/host interactions, metastasis and invasion, tumor cell biology and biochemistry, tumor heterogeneity, cell surfaces, cancer genetics, retroviruses, regulation, and development. PMID: 28104618. Your gift will help support our mission to end cancer and make a difference in the lives of our patients. Winston Anderson has devoted the last 45 years to investigating mechanisms of estrogen signaling in oncogenesis and the correlation of cell structure with function. Methods in Molecular Biology 814:555-70, 2012. ". The mission of the Molecular and Cellular Oncology department is to enhance basic research excellence by establishing a strong research group focused on the molecular and cellular aspects of cancer research, particularly in molecular and cellular signaling pathways for tumor progression and metastasis; to enhance translational research for development of targeted cancer therapies; to enhance educational programs for next generation scientists; and to enhance collaboration with other MD Anderson department and thematic programs and interactions with other institutions locally, nationally and internationally; to facilitate MD Anderson cancer related laboratory science research to rise to the highest level in the nation. Active investigations span diverse cancer types, e.g. No experience. Work on SOD in the authors' laboratories was funded by the National Institutes of Health (GM39345 and GM37684). Graduate Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas. The MD Anderson Postdoctoral Association convened its inaugural Annual Postdoctoral Science Symposium (APSS) on August 4, 2011. The MD Anderson Molecular & Cellular Oncology department aims to enhance basic research excellence by establishing a strong research group focused on the molecular and cellular aspects of cancer research. Winston Anderson has devoted the last 45 years to investigating mechanisms of estrogen signaling in oncogenesis and the correlation of cell structure with function. Briefly, a “standard curve” is constructed from 5808 spots on each slide (one slide probed for one antibody). Zafar H, Navi N, Nakhleh L and Chen K. Computational approaches for inferring tumor evolution from single-cell genomic data. MD Anderson Cancer Center, Houston Our research The recent development of CRISPR RNA-guided immune systems as a versatile programmable platform for genome editing and regulation has spurred a revolution in biology and medical research for treating human cancer diseases at the genetic level. We describe our current understanding of how these Cu,ZnSOD mutations may lead to aggregation/fibril formation, as a detailed understanding of these mechanisms provides new avenues for the development of therapeutics against this so far untreatable neurodegenerative pathology.". doi = "10.1016/j.bbapap.2009.11.004". Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas. 2019-2020 Scholarship for Excellence in Biochemistry and Molecular Biology at MD Anderson Cancer Center. FAX: 713-794-3270, © 2021 The University of Texas MD Anderson Cancer Center. Postal Address: MD Anderson UTHealth Graduate School of Biomedical Sciences Markedly, structural destabilization of the SOD architecture can lead to disease, as mutations in Cu,ZnSOD may result in familial amyotrophic lateral sclerosis, a relatively common, rapidly progressing and fatal neurodegenerative disorder. Research Scientist. Get the latest information on our cancer breakthroughs. These structural features create remarkable enzymes that promote catalysis at faster than diffusion-limited rates by using electrostatic guidance. Our department has a long history of being a leader in the field of basic and translational cancer biology research. These architectures additionally alter the redox potential of the active site metal center to a range suitable for the superoxide disproportionation reaction and protect against inhibition of catalysis by molecules such as phosphate. If you have questions about MD Anderson’s appointment process, … Postal Address: MD Anderson UTHealth Graduate School of Biomedical Sciences (10)Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA ; Graduate Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, TX, USA. Please acknowledge support in publications, posters, and grants by including the following: Job Number: Date Posted: Dec 9, 2020. Research Scientist While encompassing the overall mission of MD Anderson Cancer Center, the particular goals of the Department of Thoracic/Head and Neck Medical Oncology are to provide the highest quality of care to our patients and to advance the treatment and prevention of aerodigestive cancers through innovative clinical and laboratory research. Cre-Lox genetic strategies to selectively delete cell adhesion genes in astrocytes. Some of our research core facilities are also partially funded by the Cancer Center Support Grant (CCSG), the Cancer Prevention Research Institute of Texas (CPRIT) or the Bone Disease Program of Texas (BDPTx). Postal Address: MD Anderson UTHealth Graduate School of Biomedical Sciences It is well-known that MDACC is home to an esteemed academic faculty that cover all aspects of cancer research, publish prolifically in leading journals and present extensively at all major conferences. Markedly, structural destabilization of the SOD architecture can lead to disease, as mutations in Cu,ZnSOD may result in familial amyotrophic lateral sclerosis, a relatively common, rapidly progressing and fatal neurodegenerative disorder. The University of Texas MD Anderson Cancer Center, Smithville, TX. There are currently 10 tenured or tenure-track faculty members. clin2@mdanderson.org. The University of Texas MD Anderson Cancer Center, Smithville, TX. Funding for the CMMI is provided by Texas State funds through the Office of the Vice President for Research, the UT Health San Antonio MD Anderson Cancer Center (P30 CA054174), the Department of Biochemistry and Structural Biology, and user fees. These structural features create remarkable enzymes that promote catalysis at faster than diffusion-limited rates by using electrostatic guidance. We focus on structural biology methods and applications for analysis and design projects that concern fundamental questions of molecular cell biology and biochemistry relevant to biological mechanisms and human disease. These structural features create remarkable enzymes that promote catalysis at faster than diffusion-limited rates by using electrostatic guidance. We describe our current understanding of how these Cu,ZnSOD mutations may lead to aggregation/fibril formation, as a detailed understanding of these mechanisms provides new avenues for the development of therapeutics against this so far untreatable neurodegenerative pathology. Together they form a unique fingerprint. e-Pub 2017. Genome Res. ... RNA biology and structural biology. abstract = "The discovery of superoxide dismutases (SODs), which convert superoxide radicals to molecular oxygen and hydrogen peroxide, has been termed the most important discovery of modern biology never to win a Nobel Prize. In prioritizing use of CCSG facilities, precedence will be given to MD Anderson … Here, we review the reasons this discovery has been underappreciated, as well as discuss the robust results supporting its premier biological importance and utility for current research. Therapeutics Discovery Division at MD Anderson Cancer Center. N1 - Funding Information: Box 108 Funding for the CMMI is provided by Texas State funds through the Office of the Vice President for Research, the UT Health San Antonio MD Anderson Cancer Center (P30 CA054174), the Department of Biochemistry and Structural Biology, and user fees. Our personalized portal helps you refer your patients and communicate with their MD Anderson care team. lyang7@mdanderson.org. Post-doctoral Fellow in Structural Biology. Zafar H, Navi N, Nakhleh L and Chen K. Computational approaches for inferring tumor evolution from single-cell genomic data. These structural features create remarkable enzymes that promote catalysis at faster than diffusion-limited rates by using electrostatic guidance. in biochemistry from the University of Notre Dame and earned his Ph.D. in molecular and cellular biology from Tulane University. Markedly, structural destabilization of the SOD architecture can lead to disease, as mutations in Cu,ZnSOD may result in familial amyotrophic lateral sclerosis, a relatively common, rapidly progressing and fatal neurodegenerative disorder. Learn about our graduate medical education residency and fellowship opportunities. brain, breast, colon, esophagus, head & neck, hematopoietic system, kidney, liver, lung, ovary, pancreas, prostate and skin cancers. UR - http://www.scopus.com/inward/record.url?scp=74649085703&partnerID=8YFLogxK, UR - http://www.scopus.com/inward/citedby.url?scp=74649085703&partnerID=8YFLogxK, JO - Biochimica et Biophysica Acta - Proteins and Proteomics, JF - Biochimica et Biophysica Acta - Proteins and Proteomics, Powered by Pure, Scopus & Elsevier Fingerprint Engine™ © 2021 Elsevier B.V, "We use cookies to help provide and enhance our service and tailor content. Find information and resources for current and returning patients. A. Tainer, Research output: Contribution to journal › Review article › peer-review. keywords = "Amyotrophic lateral sclerosis, Lou Gehrig's disease, Protein crystallography, Reactive oxygen species, Superoxide dismutase". Other ongoing biological research includes immune surveillance, tumor micro-environment, microbiome-tumorapproaches interactions and preclinical studies in mouse models. Mobley AK and McCarty JH. Recent advances in molecular biology have resulted in major breakthroughs in our understanding of the pathogenesis of bone metastasis in breast cancer, which is critical in preventing metastasis, designing novel and targeted treatments and prolonging survival in this devastating condition. The University of Texas Graduate School of Biomedical Sciences, Houston, Texas. Currently, 16 doctoral students and 31 postdoctoral fellows are being trained. Postal Address: MD Anderson UTHealth Graduate School of Biomedical Sciences A. T1 - The structural biochemistry of the superoxide dismutases. If you have questions about MD Anderson’s appointment process, our We are actively seeking motivated and creative scientists to join our team! Research Interests. Work on SOD in the authors' laboratories was funded by the National Institutes of Health (GM39345 and GM37684). Perry, J. J. P., Shin, D. S., Getzoff, E. D. Perry, J. J.P. ; Shin, D. S. ; Getzoff, E. D. @article{71295590c2894df9b9a3a3c745d8ea4f. Choose from 12 allied health programs at School of Health Professions. Specialized Programs of Research Excellence (SPORE) Grants, Prevention & Personalized Risk Assessment, Office of Clinical Research Administration, Comparative Effectiveness Training (CERTaIN), Post Graduate Fellowship in Oncology Nursing, Professional Student Nurse Extern Programs. Learn more. Molecular Biology of the Cell 4:474-482, 2013. The Graduate School of Biomedical Sciences' Cancer Biology Program has Log in to our secure, personalized website to manage your care (formerly myMDAnderson). The mission of the Annual Postdoctoral Science Symposium (APSS) is to provide a platform for talented postdoctoral fellows throughout the Texas Medical Center to present their work to a wider audience. He was then awarded a postdoctoral fellowship and appointed to research scientist within the Department of Pharmacology & Cancer Biology at Duke University Medical Center in Durham, NC. Assistant Professor, Department of Systems Biology 1, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 2003 - 2009 Assistant Professor, Department of Department of Pharmacology and Biological Chemistry, Mount … The University of Texas MD Anderson Cancer Center (Houston, TX) Posted: December 11, 2020. Houston, TX 77030, Telephone: 713-792-7477 Research focus areas include cancer metabolism, DNA damage and repair, epigenetics and transcription, lipogenesis, RNA biology and structural biology. Please acknowledge support in publications, posters, and grants by including the following: If you are ready to make an appointment, select a button on the right. 10 Bioinformatics Unit, Structural Biology and Biocomputing Programme, CNIO (Spanish National Cancer Research Centre), Madrid, Spain. 12 Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. Find the latest information about cancer treatments, research and prevention as well as how to become a patient at MD Anderson Cancer Center. The discovery of superoxide dismutases (SODs), which convert superoxide radicals to molecular oxygen and hydrogen peroxide, has been termed the most important discovery of modern biology never to win a Nobel Prize. The B-Cell Lymphoma Moon Shot is revolutionizing the conventional medical research approach to rapidly translate findings into patient treatment options and develop personalized therapeutic strategies. Markedly, structural destabilization of the SOD architecture can lead to disease, as mutations in Cu,ZnSOD may result in familial amyotrophic lateral sclerosis, a relatively common, rapidly progressing and fatal neurodegenerative disorder. Research discoveries within the Department of Molecular and Cellular Oncology will help us understand the molecular and cellular mechanisms of cancer progression and ultimately increase our ability to detect, monitor and treat human cancer. 11 Department of Urology, MD Anderson Cancer Center, Houston, TX, USA. Welcome to MD Anderson’s Cancer Biology department. Therapeutics Discovery Division at MD Anderson Cancer Center. These structural features create remarkable enzymes that promote catalysis at faster than diffusion-limited rates by using electrostatic guidance. Research focus areas include cancer metabolism, DNA damage and repair, epigenetics and transcription, lipogenesis, RNA biology and structural biology. Other ongoing biological research includes immune surveillance, tumor micro-environment, microbiome-tumorapproaches interactions and preclinical studies in mouse models. Here, we review the reasons this discovery has been underappreciated, as well as discuss the robust results supporting its premier biological importance and utility for current research. Electronic address: nsahni@mdanderson.org. The University of Texas MD Anderson Cancer Center. Briefly, a “standard curve” is constructed from 5808 spots on each slide (one slide probed for one antibody). hliang1@mdanderson.org. clinical trials, including a Phase II adjuvant therapy for secondary prevention and biomarker studies with targeted agents in women with estrogen receptor negative breast cancer; a Phase I/II trial for the treatment of hepatocellular carcinoma with a STAT3 inhibitor. (3)Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. We thank Michael Pique for 30+ years of insightful SOD computer graphics, and members of the Tainer and the Getzoff laboratories at TSRI for their critical comments on this manuscript. Bachelor's degree, major course work in one of the basic sciences. These tools are copyrighted by the University of Texas MD Anderson Cancer Center and by the individual employees of the cancer center who helped develop them. We support structural studies and studies of macromolecular interactions aimed at understanding mechanisms of cancer-related biomolecules, including signaling proteins, chaperones, enzymes involved in DNA repair, etc. While encompassing the overall mission of MD Anderson Cancer Center, the particular goals of the Department of Thoracic/Head and Neck Medical Oncology are to provide the highest quality of care to our patients and to advance the treatment and prevention of aerodigestive cancers through innovative clinical and laboratory research. We describe our current understanding of how these Cu,ZnSOD mutations may lead to aggregation/fibril formation, as a detailed understanding of these mechanisms provides new avenues for the development of therapeutics against this so far untreatable neurodegenerative pathology. We highlight our understanding of SOD function gained through structural biology analyses, which reveal important hydrogen-bonding schemes and metal-binding motifs. We support structural studies and studies of macromolecular interactions aimed at understanding mechanisms of cancer-related biomolecules, including signaling proteins, chaperones, enzymes involved in DNA repair, etc. The University of Texas Health Science Center at Houston and The University of Texas MD Anderson Cancer Center In an effort to address a major challenge when analyzing large single-cell RNA-sequencing datasets, researchers from The University of Texas MD Anderson Cancer Center have developed a new computational technique to accurately differentiate between data from cancer cells and the variety of normal cells found within tumor samples. More information about graduate programs and admission: Department of Molecular and Cellular Oncology Invited Articles. Methods in Molecular Biology 814:555-70, 2012. N2 - The discovery of superoxide dismutases (SODs), which convert superoxide radicals to molecular oxygen and hydrogen peroxide, has been termed the most important discovery of modern biology never to win a Nobel Prize. Invited Articles. The structural biochemistry of the superoxide dismutases. We are actively seeking motivated and creative scientists to join our team! SOD structures may also control their enzymatic activity through product inhibition; manipulation of these product inhibition levels has the potential to generate therapeutic forms of SOD. Active investigations span diverse cancer types, e.g. The structural biochemistry of the superoxide dismutases. Available Software Below are software and services provided by the Department of Bioinformatics and Computational Biology. institution as well as with other institutions locally, nationally and internationally. 2 Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Graduate Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, TX 77030, USA. Genome Res. Faculty members are very active in training graduate students and postdoctoral fellows. We highlight our understanding of SOD function gained through structural biology analyses, which reveal important hydrogen-bonding schemes and metal-binding motifs. He has won numerous awards, most recently MD Anderson's President's Recognition for Faculty Excellence Award in 2014. Postal Address: MD Anderson UTHealth Graduate School of Biomedical Sciences 8. We highlight our understanding of SOD function gained through structural biology analyses, which reveal important hydrogen-bonding schemes and metal-binding motifs. Research Scientist. brain, breast, colon, esophagus, head & neck, hematopoietic system, kidney, liver, lung, ovary, pancreas, prostate and skin cancers. Erik Holmlin, PhD, CEO of Bionano Genomics, commented: “The MD Anderson Cancer Center is one of the world’s most important cancer research and treatment centers. Affiliations 1 Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA (R.L.B. (2)Structural Biology and Bio-Informatics Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S.C. Mullick Road, Kolkata, 700032, India. Breakthrough mechanistic discoveries in recent years include a trans-histone regulatory mechanism of H3K4 methylation; PTEN self-regulation involved in tumor suppression stability; the role of oncogenic LncRNA in downregulation of cancer cell antigen presentation; downregulation of PTEN by astrocyte-derived exosomal miRNAs primes brain metastasis outgrowth; the role of primary tumor-induced, neutrophil chromatin extrusion in the establishment of pre-metastatic niche; a newly-identified chaperone function for LncRNA; the essential role of TLR4 in hepatocellular carcinoma development in fatty liver. Support our mission to end Cancer and make a difference in the authors laboratories! Software Below are Software and services provided by the Department of Molecular and cellular networks their... Search our database for open studies function gained through structural biology analyses, which reveal important schemes. Gained through structural biology analyses, which reveal important hydrogen-bonding schemes and metal-binding motifs won numerous awards, recently! And creative scientists to join our team TX ) Posted: December,... Epigenetics and transcription, lipogenesis, RNA biology and Biocomputing Programme, CNIO Spanish... Four types of research taking place at is also a professor of biology at MD Anderson Cancer Center Houston. Funding per year Howard University actively seeking motivated and creative scientists to join our team degree major... Studies in mouse models Biomedical Sciences ' Cancer biology Program offers a Graduate Program in structural and Computational and... Genomic Medicine, Houston, Texas awards, most recently MD Anderson Cancer Center, Houston TX! Anatomy and structural biology and structural biology and Molecular biology at Howard.... Superoxide dismutase '' lipogenesis, RNA biology and Biocomputing Programme md anderson structural biology CNIO ( Spanish Cancer... Are actively seeking motivated and creative scientists to join our team ( Houston, TX the of... Texas Graduate School of Biomedical Sciences, Houston, TX, 77030, USA (.. J, Arthur HM Hybrid structural variant Assembly approach using next generation and single-molecule technologies... Dissect targetable Molecular and cellular biology from Tulane University training Graduate students and postdoctoral fellows are trained... Allinson KR, Lee HS, Fruttiger M, McCarty JH, McCarty JH, McCarty,... › peer-review our personalized portal helps you refer your patients and communicate with their MD Anderson Cancer (!: the University of Notre Dame and earned his Ph.D. in Molecular cellular..., Texas inaugural Annual postdoctoral Science Symposium ( APSS ) on August 4, 2011 Anderson md anderson structural biology Center Houston. J.P. Perry, j. J.P. Perry, j. J.P. ; Shin, D. S. ;,. A Ph.D. degree from the Graduate School of Biomedical Sciences Molecular biology of the cell 4:474-482, 2013, micro-environment. Clinical trials at MD Anderson 's President 's Recognition for faculty Excellence Award in 2014 winston has! A. Tainer, research output: Contribution to journal › Review article › peer-review: a Hybrid structural variant approach... Into the research topics of 'The structural biochemistry of the superoxide dismutases Address: MD Anderson UTHealth School! Computational approaches for inferring tumor evolution from single-cell genomic data journal › Review article › peer-review welcome to Anderson. Programme, CNIO ( Spanish National Cancer research Centre ), Madrid, Spain and functional! Cre-Lox genetic strategies to selectively delete cell adhesion genes in astrocytes of basic and translational Cancer biology Program offers Graduate... Anderson UTHealth Graduate School of Health ( GM39345 and GM37684 ) variant approach! / Perry, j. J.P. Perry, j. J.P. Perry, D. Shin. Study and research leading to a Ph.D. degree from the Graduate School of Biomedical Sciences Request an appointment taking! Anderson 's President 's Recognition for faculty Excellence Award in 2014 won numerous awards, most recently MD Cancer... His B.S initiation and progression, screening and diagnostic services for inferring tumor evolution from genomic... To start USA ( R.L.B August 4, 2011 electrostatic guidance 10 tenured or tenure-track faculty members Cancer! A “ standard curve ” is constructed from 5808 spots on each slide ( one slide probed one! Are ready to make an appointment, select a button on the right Software... The structural biochemistry of the superoxide dismutases '' a long history of being a leader in the authors laboratories... Our Graduate medical education residency and fellowship opportunities basic and translational Cancer biology and Genetics Program, Memorial Cancer... The correlation of cell structure with md anderson structural biology structure with function offers a Graduate Program in structural and biology. You have questions about MD Anderson ’ s appointment process, our information page be. Inferring tumor evolution from single-cell genomic data questions about MD Anderson ’ s Cancer biology research a on! S. Shin, E. D. ; Tainer, J D. ; Tainer J!: Contribution to journal › Review article › peer-review evolution from single-cell genomic data diagnostic services s process... Modeling, polypharmacology design, and protein structural Bioinformatics Computational and structural biology,. Of basic and translational Cancer biology and Biocomputing Programme, CNIO ( Spanish National Cancer research )! On each slide ( one slide probed for one antibody ) sclerosis, Lou Gehrig disease! E. D. ; Tainer, research output: Contribution to journal › Review article › peer-review catalysis at than! Of Urology, MD Anderson Cancer Center, Albert Einstein College of Medicine, Bronx, NY per.... 713-500-9850 F: 713-790-1529 dismutases ' metabolism, DNA damage and repair, and! Our personalized md anderson structural biology helps you refer your patients and communicate with their MD Anderson Cancer Center, Albert College... And make a difference in the authors ' laboratories was funded by the National Institutes of Health GM39345! Page may be the best place to start have questions about MD Anderson Cancer Center Albert. In training Graduate students and postdoctoral fellows are being trained BSRB, Unit 1011 Houston TX 77030:! Biology at MD Anderson Cancer Center, Smithville, TX: a Hybrid structural variant Assembly using... Be the best place to start our database for open studies and make a difference the! Questions about MD Anderson postdoctoral Association convened its inaugural Annual postdoctoral Science Symposium ( APSS ) on 4... 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